VIP-IN activation in motor cortex improves motor deficits in Huntington's disease mouse models
UNVERIFIED·Primary source · Nature
Researchers identified VIP-expressing inhibitory neurons (VIP-INs) as a key therapeutic target in Huntington's disease (HD).
In R6/2 and zQ175DN mouse models, VIP-IN hypoactivity leads to cortical circuit dysfunction and motor deficits.
Optogenetic activation of VIP-INs restores cortical network balance and provides sustained improvement in motor performance.
Key Facts
01
01 — What / Thesis
VIP-IN activation in motor cortex improves motor deficits in Huntington's disease mouse models
02
02 — Who / Subject
Sonja Blumenstock, Irina Dudanova, Takaki Komiyama, and research teams at UCSD and Max Planck Institute
03
03 — Where / Locus
La Jolla, USA and Martinsried, Germany
04
04 — When / Temporality
June 2026
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